Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis
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چکیده
منابع مشابه
De Novo Lipogenesis Products and Endogenous Lipokines
Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlights this somewhat less apparent biology of lipids, especially focusing on de novo lipogenesis as ...
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The role of carbonic anhydrase in de novo lipid synthesis was examined by measuring [1-14C]acetate incorporation into total lipids, fatty acids and non-saponifiable lipids in freshly isolated rat hepatocytes. Two carbonic anhydrase inhibitors, trifluoromethylsulphonamide (TFMS) and ethoxozolamide (ETZ) decreased incorporation of 14C into total lipids. Both fatty acid and non-saponifiable lipid ...
متن کاملAdipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with H2O
Strawford, A., F. Antelo, M. Christiansen, and M. K. Hellerstein. Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with H2O. Am J Physiol Endocrinol Metab 286: E577–E588, 2004. First published November 4, 2003; 10.1152/ajpendo.00093.2003.—The turnover of adipose tissue components (lipids and cells) and the pathways of adipose lipid deposition ...
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Increased de novo lipogenesis is being increasingly recognized as a hallmark of cancer. Despite recent advances in fluorescence microscopy, autoradiography and mass spectrometry, direct observation of de novo lipogenesis in living systems remains to be challenging. Here, by coupling stimulated Raman scattering (SRS) microscopy with isotope labeled glucose, we were able to trace the dynamic meta...
متن کاملAdipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O.
The turnover of adipose tissue components (lipids and cells) and the pathways of adipose lipid deposition have been difficult to measure in humans. We apply here a (2)H(2)O long-term labeling technique for concurrent measurement of adipose-triglyceride (TG) turnover, cell (DNA) proliferation, and de novo lipogenesis (DNL). Healthy subjects drank (2)H(2)O (70 ml/day) for 5-9 wk. Subcutaneous adi...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2015
ISSN: 1756-0500
DOI: 10.1186/s13104-015-1016-0